Modular 'click-in-emulsion' bone-targeted nanogels.
Ontology highlight
ABSTRACT:
SUBMITTER: Heller DA
PROVIDER: S-EPMC3815631 | biostudies-literature | 2013 Mar
REPOSITORIES: biostudies-literature
Publications
Modular 'click-in-emulsion' bone-targeted nanogels.
Heller Daniel A DA Levi Yair Y Pelet Jeisa M JM Doloff Joshua C JC Wallas Jasmine J Pratt George W GW Jiang Shan S Sahay Gaurav G Schroeder Avi A Schroeder Josh E JE Chyan Yieu Y Zurenko Christopher C Querbes William W Manzano Miguel M Kohane Daniel S DS Langer Robert R Anderson Daniel G DG
Advanced materials (Deerfield Beach, Fla.) 20121227 10
A new class of nanogel demonstrates modular biodistribution and affinity for bone. Nanogels, ∼70 nm in diameter and synthesized via an astoichiometric click-chemistry in-emulsion method, controllably display residual, free clickable functional groups. Functionalization with a bisphosphonate ligand results in significant binding to bone on the inner walls of marrow cavities, liver avoidance, and anti-osteoporotic effects. ...[more]
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