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Higher serum iron is associated with increased oxidant stress in HIV-infected men.

ABSTRACT: BACKGROUND:F?-isoprostanes (F?-IsoP) are oxidant stress biomarkers that are higher in HIV-infected women than men. We explored whether the effect of hemoglobin (Hgb), serum iron, or anemia on F?-IsoP is different between HIV-infected women and men. METHODS:Plasma F?-IsoP were quantified by gas chromatography/mass spectrometry; clinical and laboratory data were collected at enrollment or from the medical record. Multivariable linear regression was used to assess associations between F?-IsoP and Hgb, anemia as a dichotomous variable, and serum iron with adjustment for age, sex, race, body mass index, CD4 lymphocyte count, self-reported current smoking status, and antiretroviral therapy. RESULTS:Compared with men, women had lower Hgb [median: 12.7 (interquartile range: 11.8-13.9) vs. 14.9 (13.7-15.8) g/dL, P < 0.001], lower iron levels [75 (47-97) vs. 90 (69-121) µg/dL, P = 0.004], more anemia (29% vs. 10%, P < 0.001), and higher levels of F?-IsoP [42 (32-62) vs. 36 (25-46) pg/mL, P < 0.001]. The relationship between iron and F?-IsoP differed significantly between men and women (interaction P = 0.02). Men had a 21% (95% confidence interval: 8 to 36) increase in F?-IsoP per interquartile increase in iron (P = 0.001), whereas no relationship was seen among women [-4% (-17 to 13, P = 0.65]. CONCLUSIONS:Although women have overall higher F?-IsoP than men, a relationship between circulating F?-IsoP and iron levels was observed in men but not in women with HIV infection. The association between female sex and higher F?-IsoP is not explained by iron or Hgb levels because the association persists when controlling for these factors. The role of iron in oxidant stress and sex-specific differences among HIV-infected individuals require further study.

SUBMITTER: Crist MB

PROVIDER: S-EPMC3816092 | biostudies-literature | 2013 Dec

REPOSITORIES: biostudies-literature

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Higher serum iron is associated with increased oxidant stress in HIV-infected men.

Crist Matthew B MB Melekhin Vlada V VV Bian Aihua A Shintani Ayumi A Milne Ginger L GL Kallianpur Asha R AR Dageforde Leigh A LA Haas David W DW Hulgan Todd T

Journal of acquired immune deficiency syndromes (1999) 20131201 4

<h4>Background</h4>F₂-isoprostanes (F₂-IsoP) are oxidant stress biomarkers that are higher in HIV-infected women than men. We explored whether the effect of hemoglobin (Hgb), serum iron, or anemia on F₂-IsoP is different between HIV-infected women and men.<h4>Methods</h4>Plasma F₂-IsoP were quantified by gas chromatography/mass spectrometry; clinical and laboratory data were collected at enrollment or from the medical record. Multivariable linear regression was used to assess associations betwee ...[more]

PMID: 24169121

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Higher serum iron is associated with increased oxidant stress in HIV-infected men.

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Higher serum iron is associated with increased oxidant stress in HIV-infected men.

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