Vitamin D3 effects on lipids differ in statin and non-statin-treated humans: superiority of free 25-OH D levels in detecting relationships.

ABSTRACT:

Context

Inverse associations between 25-OH vitamin D levels and cardiovascular morbidity and mortality have been reported.

Objectives

Our goals were to 1) investigate effects of correcting inadequate D status on lipids, 2) determine whether free 25-OH D is better correlated with lipids than total 25-OH D.

Design

A randomized, double-blind placebo-controlled trial was performed.

Setting

Participants resided in the general community.

Participants

Adults with inadequate D status were randomized to D3: 14 men, 12 women, age 60 ± 8 years (mean ± SD) or placebo: 12 men, 11 women: 59 ±12 years.

Intervention

Responses to 12-week oral vitamin D3 titrated (1000-3000 IU/d) to achieve 25-OH D levels ≥25 ng/mL were compared to placebo.

Main outcome measures

SUBMITTER: Kane L 

PROVIDER: S-EPMC3816263 | biostudies-literature | 2013 Nov

REPOSITORIES: biostudies-literature