Ontology highlight
ABSTRACT:
SUBMITTER: Baudhuin J
PROVIDER: S-EPMC3816409 | biostudies-literature | 2013 Oct
REPOSITORIES: biostudies-literature
Baudhuin Jeremy J Migraine Julie J Faivre Valerie V Loumagne Laure L Lukaszewicz Anne-Claire AC Payen Didier D Favier Benoit B
Proceedings of the National Academy of Sciences of the United States of America 20131016 44
Neutrophils play a major role in inflammatory responses and immune defense against pathogens. Even though expression of inhibitory receptors has been reported on neutrophils, their role remains poorly defined. Here we show that primary human neutrophils expressed immunoglobulin-like transcript 4 (ILT4) inhibitory receptor and that this expression was induced during differentiation of the myelomonoblast PLB-985 cell line into "neutrophil-like" cells. Functional assays indicated that human leukocy ...[more]