Ontology highlight
ABSTRACT:
SUBMITTER: Cao S
PROVIDER: S-EPMC4560393 | biostudies-literature | 2015
REPOSITORIES: biostudies-literature
Cao Shannan S Liu Peng P Zhu Haiyan H Gong Haiyan H Yao Jianfeng J Sun Yawei Y Geng Guangfeng G Wang Tong T Feng Sizhou S Han Mingzhe M Zhou Jiaxi J Xu Yuanfu Y
PloS one 20150904 9
In human pathological conditions, the acidification of local environment is a frequent feature, such as tumor and inflammation. As the pH of microenvironment alters, the functions of immune cells are about to change. It makes the extracellular acidification a key modulator of innate immunity. Here we detected the impact of extracellular acidification on neutrophil apoptosis and functions, including cell death, respiratory burst, migration and phagocytosis. As a result, we found that under the ac ...[more]