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Extracellular Acidification Acts as a Key Modulator of Neutrophil Apoptosis and Functions.


ABSTRACT: In human pathological conditions, the acidification of local environment is a frequent feature, such as tumor and inflammation. As the pH of microenvironment alters, the functions of immune cells are about to change. It makes the extracellular acidification a key modulator of innate immunity. Here we detected the impact of extracellular acidification on neutrophil apoptosis and functions, including cell death, respiratory burst, migration and phagocytosis. As a result, we found that under the acid environment, neutrophil apoptosis delayed, respiratory burst inhibited, polarization augmented, chemotaxis differed, endocytosis enhanced and bacteria killing suppressed. These findings suggested that extracellular acidification acts as a key regulator of neutrophil apoptosis and functions.

SUBMITTER: Cao S 

PROVIDER: S-EPMC4560393 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature

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Extracellular Acidification Acts as a Key Modulator of Neutrophil Apoptosis and Functions.

Cao Shannan S   Liu Peng P   Zhu Haiyan H   Gong Haiyan H   Yao Jianfeng J   Sun Yawei Y   Geng Guangfeng G   Wang Tong T   Feng Sizhou S   Han Mingzhe M   Zhou Jiaxi J   Xu Yuanfu Y  

PloS one 20150904 9


In human pathological conditions, the acidification of local environment is a frequent feature, such as tumor and inflammation. As the pH of microenvironment alters, the functions of immune cells are about to change. It makes the extracellular acidification a key modulator of innate immunity. Here we detected the impact of extracellular acidification on neutrophil apoptosis and functions, including cell death, respiratory burst, migration and phagocytosis. As a result, we found that under the ac  ...[more]

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