Ontology highlight
ABSTRACT:
SUBMITTER: Iancu CV
PROVIDER: S-EPMC3816430 | biostudies-literature | 2013 Oct
REPOSITORIES: biostudies-literature
Iancu Cristina V CV Zamoon Jamillah J Woo Sang Bum SB Aleshin Alexander A Choe Jun-yong JY
Proceedings of the National Academy of Sciences of the United States of America 20131014 44
Glucose transporters are required to bring glucose into cells, where it is an essential energy source and precursor in protein and lipid synthesis. These transporters are involved in important common diseases such as cancer and diabetes. Here, we report the crystal structure of the Staphylococcus epidermidis glucose/H(+) symporter in an inward-facing conformation at 3.2-Å resolution. The Staphylococcus epidermidis glucose/H(+) symporter is homologous to human glucose transporters, is very specif ...[more]