Ontology highlight
ABSTRACT:
SUBMITTER: Chen Z
PROVIDER: S-EPMC3817295 | biostudies-literature | 2013 Aug
REPOSITORIES: biostudies-literature
Chen Zuojia Z Barbi Joseph J Bu Shurui S Yang Huang-Yu HY Li Zhiyuan Z Gao Yayi Y Jinasena Dilini D Fu Juan J Lin Fang F Chen Chen C Zhang Jing J Yu Ning N Li Xiangpei X Shan Zhao Z Nie Jia J Gao Zhimei Z Tian Hong H Li Yangyang Y Yao Zhengju Z Zheng Ying Y Park Benjamin V BV Pan Ziyi Z Zhang Jing J Dang Eric E Li Zhiguang Z Wang Honglin H Luo Weibo W Li Liwu L Semenza Gregg L GL Zheng Song-Guo SG Loser Karin K Tsun Andy A Greene Mark I MI Pardoll Drew M DM Pan Fan F Li Bin B
Immunity 20130801 2
Regulatory T (Treg) cells suppress inflammatory immune responses and autoimmunity caused by self-reactive T cells. The key Treg cell transcription factor Foxp3 is downregulated during inflammation to allow for the acquisition of effector T cell-like functions. Here, we demonstrate that stress signals elicited by proinflammatory cytokines and lipopolysaccharides lead to the degradation of Foxp3 through the action of the E3 ubiquitin ligase Stub1. Stub1 interacted with Foxp3 to promote its K48-lin ...[more]