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Stereoselective synthesis of the C79-C97 fragment of symbiodinolide.

ABSTRACT: Symbiodinolide is a polyol marine natural product with a molecular weight of 2860. Herein, a streamlined synthesis of the C79-C97 fragment of symbiodinolide is described. In the synthetic route, a spiroacetalization, a Julia-Kocienski olefination, and a Sharpless asymmetric dihydroxylation were utilized as the key transformations.

SUBMITTER: Takamura H

PROVIDER: S-EPMC3817580 | biostudies-literature | 2013

REPOSITORIES: biostudies-literature

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Stereoselective synthesis of the C79-C97 fragment of symbiodinolide.

Takamura Hiroyoshi H Fujiwara Takayuki T Kadota Isao I Uemura Daisuke D

Beilstein journal of organic chemistry 20130925

Symbiodinolide is a polyol marine natural product with a molecular weight of 2860. Herein, a streamlined synthesis of the C79-C97 fragment of symbiodinolide is described. In the synthetic route, a spiroacetalization, a Julia-Kocienski olefination, and a Sharpless asymmetric dihydroxylation were utilized as the key transformations. ...[more]

PMID: 24204403

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