Cohesin and the nucleolus constrain the mobility of spontaneous repair foci.
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ABSTRACT:
SUBMITTER: Dion V
PROVIDER: S-EPMC3818071 | biostudies-literature | 2013 Nov
REPOSITORIES: biostudies-literature
Publications
Cohesin and the nucleolus constrain the mobility of spontaneous repair foci.
Dion Vincent V Kalck Véronique V Seeber Andrew A Schleker Thomas T Gasser Susan M SM
EMBO reports 20130910 11
The regulation of chromatin mobility in response to DNA damage is important for homologous recombination in yeast. Anchorage reduces rates of recombination, whereas increased chromatin mobility correlates with more efficient homology search. Here we tracked the mobility and localization of spontaneous S-phase lesions bound by Rad52, and find that these foci have reduced movement, unlike enzymatically induced double-strand breaks. Moreover, spontaneous repair foci are positioned in the nuclear co ...[more]
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