Ontology highlight
ABSTRACT:
SUBMITTER: Kong X
PROVIDER: S-EPMC3911484 | biostudies-literature | 2014 Feb
REPOSITORIES: biostudies-literature
Kong Xiangduo X Ball Alexander R AR Pham Hoang Xuan HX Zeng Weihua W Chen Hsiao-Yuan HY Schmiesing John A JA Kim Jong-Soo JS Berns Michael M Yokomori Kyoko K
Molecular and cellular biology 20131209 4
Cohesin is an essential multiprotein complex that mediates sister chromatid cohesion critical for proper segregation of chromosomes during cell division. Cohesin is also involved in DNA double-strand break (DSB) repair. In mammalian cells, cohesin is involved in both DSB repair and the damage checkpoint response, although the relationship between these two functions is unclear. Two cohesins differing by one subunit (SA1 or SA2) are present in somatic cells, but their functional specificities wit ...[more]