Ontology highlight
ABSTRACT:
SUBMITTER: Garvin AJ
PROVIDER: S-EPMC3818072 | biostudies-literature | 2013 Nov
REPOSITORIES: biostudies-literature
Garvin Alexander J AJ Densham Ruth M RM Blair-Reid Sarah A SA Pratt Kenny M KM Stone Helen R HR Weekes Daniel D Lawrence Kirsty J KJ Morris Joanna R JR
EMBO reports 20130910 11
SUMO conjugation is known to occur in response to double-stranded DNA breaks in mammalian cells, but whether SUMO deconjugation has a role remains unclear. Here, we show that the SUMO/Sentrin/Smt3-specific peptidase, SENP7, interacts with the chromatin repressive KRAB-associated protein 1 (KAP1) through heterochromatin protein 1 alpha (HP1α). SENP7 promotes the removal of SUMO2/3 from KAP1 and regulates the interaction of the chromatin remodeler CHD3 with chromatin. Consequently, in the presence ...[more]