Ontology highlight
ABSTRACT:
SUBMITTER: Maranon DG
PROVIDER: S-EPMC7659731 | biostudies-literature | 2020 Oct
REPOSITORIES: biostudies-literature
Maranon David G DG Sharma Neelam N Huang Yuxin Y Selemenakis Platon P Wang Meiling M Altina Noelia N Zhao Weixing W Wiese Claudia C
The Journal of cell biology 20201001 10
NUCKS1 (nuclear ubiquitous casein kinase and cyclin-dependent kinase substrate 1) is a chromatin-associated, vertebrate-specific, and multifunctional protein with a role in DNA damage signaling and repair. Previously, we have shown that NUCKS1 helps maintain homologous recombination (HR) DNA repair in human cells and functions as a tumor suppressor in mice. However, the mechanisms by which NUCKS1 positively impacts these processes had remained unclear. Here, we show that NUCKS1 physically and fu ...[more]