Ontology highlight
ABSTRACT:
SUBMITTER: Squatrito M
PROVIDER: S-EPMC3818087 | biostudies-literature | 2010 Dec
REPOSITORIES: biostudies-literature
Cancer cell 20101201 6
Maintenance of genomic integrity is essential for adult tissue homeostasis and defects in the DNA-damage response (DDR) machinery are linked to numerous pathologies including cancer. Here, we present evidence that the DDR exerts tumor suppressor activity in gliomas. We show that genes encoding components of the DDR pathway are frequently altered in human gliomas and that loss of elements of the ATM/Chk2/p53 cascade accelerates tumor formation in a glioma mouse model. We demonstrate that Chk2 is ...[more]