Ontology highlight
ABSTRACT:
SUBMITTER: Korenbrot JI
PROVIDER: S-EPMC3818550 | biostudies-literature | 2013 Nov
REPOSITORIES: biostudies-literature
Korenbrot Juan I JI Mehta Milap M Tserentsoodol Nomingerel N Postlethwait John H JH Rebrik Tatiana I TI
The Journal of neuroscience : the official journal of the Society for Neuroscience 20131101 45
The ligand sensitivity of cGMP-gated (CNG) ion channels in cone photoreceptors is modulated by CNG-modulin, a Ca(2+)-binding protein. We investigated the functional role of CNG-modulin in phototransduction in vivo in morpholino-mediated gene knockdown zebrafish. Through comparative genomic analysis, we identified the orthologue gene of CNG-modulin in zebrafish, eml1, an ancient gene present in the genome of all vertebrates sequenced to date. We compare the photoresponses of wild-type cones with ...[more]