Ontology highlight
ABSTRACT:
SUBMITTER: Cinalli RM
PROVIDER: S-EPMC3818562 | biostudies-literature | 2013 Jul
REPOSITORIES: biostudies-literature
Cinalli Ryan M RM Lehmann Ruth R
Nature cell biology 20130602 7
The primordial germ cells (PGCs) are the first cells to form during Drosophila melanogaster embryogenesis. Whereas the process of somatic cell formation has been studied in detail, the mechanics of PGC formation are poorly understood. Here, using four-dimensional multi-photon imaging combined with genetic and pharmacological manipulations, we find that PGC formation requires an anaphase spindle-independent cleavage pathway. In addition to using core regulators of cleavage, including the small GT ...[more]