Ontology highlight
ABSTRACT:
SUBMITTER: Tan Q
PROVIDER: S-EPMC3819204 | biostudies-literature | 2013 Sep
REPOSITORIES: biostudies-literature
Science (New York, N.Y.) 20130912 6152
The CCR5 chemokine receptor acts as a co-receptor for HIV-1 viral entry. Here we report the 2.7 angstrom-resolution crystal structure of human CCR5 bound to the marketed HIV drug maraviroc. The structure reveals a ligand-binding site that is distinct from the proposed major recognition sites for chemokines and the viral glycoprotein gp120, providing insights into the mechanism of allosteric inhibition of chemokine signaling and viral entry. A comparison between CCR5 and CXCR4 crystal structures, ...[more]