Interactions between alcohol and the HIV entry inhibitor Maraviroc.

ABSTRACT: Alcohol use is common among people with HIV, and beliefs about alcohol interactions with medications predict decreased medication adherence, risking drug-resistant mutations. Maraviroc is an HIV entry inhibitor approved for treatment of both drug-sensitive and drug-resistant HIV strains. The present study evaluated the effects of alcohol on maraviroc pharmacokinetics and the effects of maraviroc on alcohol pharmacokinetics.Ten healthy adults completed alcohol (1 g/kg) and placebo alcohol pharmacokinetics sessions before and after 7 days of maraviroc administration.Alcohol concentrations increased 12% following maraviroc. Maraviroc pharmacokinetics were unaffected by alcohol.Maraviroc treatment should not be interrupted if alcohol is consumed.

SUBMITTER: Gruber VA 

PROVIDER: S-EPMC4100473 | biostudies-literature | 2013 Nov-Dec

REPOSITORIES: biostudies-literature