Ontology highlight
ABSTRACT:
SUBMITTER: Li X
PROVIDER: S-EPMC3819285 | biostudies-literature | 2013
REPOSITORIES: biostudies-literature
Li Xiaofei X Wang Jing J Wang Wei W Liu Chunhong C Sun Shuhui S Gu Jianxin J Wang Xun X Boraschi Diana D Huang Yuxian Y Qu Di D
PloS one 20131106 11
Natural β-glucans extracted from plants and fungi have been used in clinical therapies since the late 20th century. However, the heterogeneity of natural β-glucans limits their clinical applicability. We have synthesized β-glu6, which is an analog of the lentinan basic unit, β-(1→6)-branched β-(1→3) glucohexaose, that contains an α-(1→3)-linked bond. We have demonstrated the stimulatory effect of this molecule on the immune response, but the mechanisms by which β-glu6 activates innate immunity h ...[more]