Ontology highlight
ABSTRACT:
SUBMITTER: Eslam M
PROVIDER: S-EPMC3819540 | biostudies-literature | 2013 Nov
REPOSITORIES: biostudies-literature
Eslam Mohammed M Booth David R DR George Jacob J Ahlenstiel Golo G
World journal of gastroenterology 20131101 41
Metabolic changes are inextricably linked to chronic hepatitis C (CHC). Recently polymorphisms in the IFNL3 (IL28B) region have been shown to be strongly associated with spontaneous and treatment induced recovery from hepatitis C virus (HCV) infection. Further, circumstantial evidence suggests a link between IFNL3 single nucleotide polymorphisms and lipid metabolism, steatosis and insulin resistance in CHC. The emerging picture suggests that the responder genotypes of IFNL3 polymorphisms are ass ...[more]