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Detection of Leishmania siamensis DNA in saliva by polymerase chain reaction.


ABSTRACT: Polymerase chain reaction was used to detect Leishmania siamensis DNA from clinical samples collected from six leishmaniasis patients during 2011-2012. The samples used in this study came from bone marrow, blood, buffy coat, saliva, urine, and tissue biopsy specimens. Saliva was a good source for L. siamensis DNA by polymerase chain reaction. L. siamensis DNA was also found in saliva of an asymptomatic case-patient. Levels of L. siamensis DNA in saliva decreased until being undetectable after treatment. These levels could be used as a marker to evaluate efficacy of the treatment. A larger study is needed to evaluate this method as a screening and survey tool to study the silent background of Leishmania infection among the at-risk population.

SUBMITTER: Phumee A 

PROVIDER: S-EPMC3820333 | biostudies-literature | 2013 Nov

REPOSITORIES: biostudies-literature

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Detection of Leishmania siamensis DNA in saliva by polymerase chain reaction.

Phumee Atchara A   Kraivichian Kanyarat K   Chusri Sarunyou S   Noppakun Nopadon N   Vibhagool Asda A   Sanprasert Vivornpun V   Tampanya Vich V   Wilde Henry H   Siriyasatien Padet P  

The American journal of tropical medicine and hygiene 20130923 5


Polymerase chain reaction was used to detect Leishmania siamensis DNA from clinical samples collected from six leishmaniasis patients during 2011-2012. The samples used in this study came from bone marrow, blood, buffy coat, saliva, urine, and tissue biopsy specimens. Saliva was a good source for L. siamensis DNA by polymerase chain reaction. L. siamensis DNA was also found in saliva of an asymptomatic case-patient. Levels of L. siamensis DNA in saliva decreased until being undetectable after tr  ...[more]

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