Ontology highlight
ABSTRACT:
SUBMITTER: Zhang X
PROVIDER: S-EPMC3820842 | biostudies-literature | 2009 Apr
REPOSITORIES: biostudies-literature
Zhang Xiaoying X Liu Dongyun D Lv Shuang S Wang Haibo H Zhong Xueyan X Liu Bo B Wang Bo B Liao Ji J Li Jing J Pfeifer Gerd P GP Xu Xingzhi X
Cell cycle (Georgetown, Tex.) 20090416 8
The combination of paclitaxel and doxorubicin is among the most successful chemotherapy regimens in cancer treatment. CDK5RAP2, when mutated, causes primary microcephaly. We show here that inhibition of CDK5RAP2 expression causes chromosome mis-segregation, fails to maintain the spindle checkpoint, and is associated with reduced expression of the spindle checkpoint proteins BUBR1 and MAD2 and an increase in chromatin-associated CDC20. CDK5RAP2 resides on the BUBR1 and MAD2 promoters and regulate ...[more]