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IL-17 cytokines in immunity and inflammation.

ABSTRACT: Interleukin 17 (IL-17) and its closest relative, IL-17F, have recently drawn much attention in the field of immunology. IL-17 and IL-17F are expressed by a distinct type of T cells, T helper 17 cells and certain other lymphocytes. These cytokines play key regulatory roles in host defense and inflammatory diseases. In this review, we summarize the recent findings in IL-17 biology and the progress towards understanding the regulatory mechanisms of IL-17 expression and signaling mechanisms. This knowledge will benefit the development of novel immune modulators that enhance immunity to various infections and reduce inflammatory damage in infected patients.

SUBMITTER: Jin W

PROVIDER: S-EPMC3820987 | biostudies-literature | 2013 Sep

REPOSITORIES: biostudies-literature

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IL-17 cytokines in immunity and inflammation.

Jin Wei W Dong Chen C

Emerging microbes & infections 20130918 9

Interleukin 17 (IL-17) and its closest relative, IL-17F, have recently drawn much attention in the field of immunology. IL-17 and IL-17F are expressed by a distinct type of T cells, T helper 17 cells and certain other lymphocytes. These cytokines play key regulatory roles in host defense and inflammatory diseases. In this review, we summarize the recent findings in IL-17 biology and the progress towards understanding the regulatory mechanisms of IL-17 expression and signaling mechanisms. This kn ...[more]

PMID: 26038490

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Signaling of interleukin-17 family cytokines in immunity and inflammation.

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Antibody blockade of IL-17-family cytokines in immunity to acute murine oral mucosal candidiasis

Project description:IL17A KO mouse tongues after 2 days of C. albicans infection were profiled and compared to WT. In addition, tongues from animals infected for 2 days with C. albicans and then treated with anti-IL17A antibody, anti-IL17F antibody, anti-IL17A and anti-IL17F antibodies together, or isotypes controls were analyzed.

2015-12-21 | E-MTAB-4167 | biostudies-arrayexpress

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