Ontology highlight
ABSTRACT:
SUBMITTER: Li J
PROVIDER: S-EPMC5975098 | biostudies-literature | 2018 May
REPOSITORIES: biostudies-literature
Li J J Casanova J-L JL Puel A A
Mucosal immunology 20171129 3
Interleukin (IL)-17A is a pro-inflammatory cytokine in mice and humans. It is recognized as a key factor for the protection of mice against various pathogens, but it also underlies pathogenic inflammatory responses in numerous mouse models. The inborn errors of IL-17A- and IL-17F-mediated immunity identified in humans in the last decade have revealed that IL-17A and IL-17F are key players in mucocutaneous immunity to Candida albicans, and, to a lesser extent, Staphylococcus aureus. By contrast, ...[more]