Ontology highlight
ABSTRACT:
SUBMITTER: Lin DL
PROVIDER: S-EPMC3821527 | biostudies-literature | 2013 Oct
REPOSITORIES: biostudies-literature
Lin David L DL Tran Tung T Adams Christina C Alam Jamal Y JY Herron Steven R SR Tolmasky Marcelo E ME
Bioorganic & medicinal chemistry letters 20130812 20
AAC(6')-Ib is an important aminoglycoside resistance enzyme to target with enzymatic inhibitors. An in silico screening approach was used to identify potential inhibitors from the ChemBridge library. Several compounds were identified, of which two of them, 4-[(2-{[1-(3-methylphenyl)-4,6-dioxo-2-thioxotetrahydro-5(2H)-pyrimidinylidene]methyl}phenoxy)methyl]benzoic acid and 2-{5-[(4,6-dioxo-1,3-diphenyl-2-thioxotetrahydro-5(2H)-pyrimidinylidene)methyl]-2-furyl}benzoic acid, showed micromolar activ ...[more]