Ontology highlight
ABSTRACT:
SUBMITTER: Nair V
PROVIDER: S-EPMC7694325 | biostudies-literature | 2020 Nov
REPOSITORIES: biostudies-literature
Nair Vimal V Kim Min Cheol MC Golen James A JA Rheingold Arnold L AL Castro Gabriel A GA Jensen Paul R PR Fenical William W
Marine drugs 20201105 11
A new cytotoxic thiodepsipeptide, verrucosamide (<b>1</b>), was isolated along with the known, related cyclic peptide thiocoraline, from the extract of a marine-derived actinomycete, a <i>Verrucosispora</i> sp., our strain CNX-026. The new peptide, which is composed of two rare seven-membered 1,4-thiazepane rings, was elucidated by a combination of spectral methods and the absolute configuration was determined by a single X-ray diffraction study. Verrucosamide (<b>1</b>) showed moderate cytotoxi ...[more]