Unknown

Dataset Information

0

Paramagnetic 19F NMR and Electrospray Ionization Mass Spectrometric Studies of Substituted Pyridine Complexes of Chromium(III): Models for Potential Use of 19F NMR to Probe Cr(III)-Nucleotide Interaction.


ABSTRACT: The synthesis and characterization of chromium basic carboxylate complexes, [Cr3(O2CR)6L3]+, containing trifluoroacetate, 3-fluoropyridine, 3-trifluoromethylpyridine, and 4-trifluoromethylpyridine are described. The substituted pyridine ligands are used as models of DNA bases to determine whether 19F NMR would be a potentially useful probe of the binding of Cr3+ to DNA. The 19F NMR resonances of the coordinated ligands, while broadened by delocalization of unpaired electron density from the S=3/2 chromic centers, are readily discernable, and the contact shifts are of sufficient magnitude that the signals from coordinated and free ligands can easily be differentiated. Thus, 19F NMR appears to be a potentially useful probe of the binding of Cr3+ to DNA containing F-labeled bases. Additionally, electrospray MS is shown to be a convenient method to establish the identity of chromium basic carboxylate assemblies.

SUBMITTER: Rhodes NR 

PROVIDER: S-EPMC3821766 | biostudies-literature | 2013 Nov

REPOSITORIES: biostudies-literature

altmetric image

Publications

Paramagnetic <sup>19</sup>F NMR and Electrospray Ionization Mass Spectrometric Studies of Substituted Pyridine Complexes of Chromium(III): Models for Potential Use of <sup>19</sup>F NMR to Probe Cr(III)-Nucleotide Interaction.

Rhodes Nicholas R NR   Belmore Ken K   Cassady Carolyn J CJ   Vincent John B JB  

Polyhedron 20131101


The synthesis and characterization of chromium basic carboxylate complexes, [Cr<sub>3</sub>(O<sub>2</sub>CR)<sub>6</sub>L<sub>3</sub>]<sup>+</sup>, containing trifluoroacetate, 3-fluoropyridine, 3-trifluoromethylpyridine, and 4-trifluoromethylpyridine are described. The substituted pyridine ligands are used as models of DNA bases to determine whether <sup>19</sup>F NMR would be a potentially useful probe of the binding of Cr<sup>3+</sup> to DNA. The <sup>19</sup>F NMR resonances of the coordinat  ...[more]

Similar Datasets

| S-EPMC6268470 | biostudies-literature
| S-EPMC7092367 | biostudies-literature
| S-EPMC9285442 | biostudies-literature
| S-EPMC3006931 | biostudies-literature
| S-EPMC3867692 | biostudies-literature
| S-EPMC3158606 | biostudies-literature
| S-EPMC5380053 | biostudies-literature
| S-EPMC2747347 | biostudies-literature
| S-EPMC3884409 | biostudies-literature
| S-EPMC6895946 | biostudies-literature