Exhaustion of racing sperm in nature-mimicking microfluidic channels during sorting.
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ABSTRACT:
SUBMITTER: Tasoglu S
PROVIDER: S-EPMC3821799 | biostudies-literature | 2013 Oct
REPOSITORIES: biostudies-literature
Publications
Exhaustion of racing sperm in nature-mimicking microfluidic channels during sorting.
Tasoglu Savas S Safaee Hooman H Zhang Xiaohui X Kingsley James L JL Catalano Paolo N PN Gurkan Umut Atakan UA Nureddin Aida A Kayaalp Emre E Anchan Raymond M RM Maas Richard L RL Tüzel Erkan E Demirci Utkan U
Small (Weinheim an der Bergstrasse, Germany) 20130516 20
Fertilization is central to the survival and propagation of a species, however, the precise mechanisms that regulate the sperm's journey to the egg are not well understood. In nature, the sperm has to swim through the cervical mucus, akin to a microfluidic channel. Inspired by this, a simple, cost-effective microfluidic channel is designed on the same scale. The experimental results are supported by a computational model incorporating the exhaustion time of sperm. ...[more]
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