Ontology highlight
ABSTRACT:
SUBMITTER: Gettins PG
PROVIDER: S-EPMC3821923 | biostudies-literature | 2009 Nov
REPOSITORIES: biostudies-literature
Gettins Peter G W PG Olson Steven T ST
FEBS letters 20091009 21
Allosteric activation of antithrombin as a rapid inhibitor of factors IXa and Xa requires binding of a high-affinity heparin pentasaccharide. The currently-accepted mechanism involves removal of a constraint on the antithrombin reactive center loop (RCL) so that the proteinase can simultaneously engage both the P1 arginine and an exosite at Y253. Recent results suggest that this mechanism is incorrect in that activation can be achieved without loop expulsion, while the exosite can be engaged in ...[more]