Activation of transposable elements during aging and neuronal decline in Drosophila.
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ABSTRACT:
SUBMITTER: Li W
PROVIDER: S-EPMC3821974 | biostudies-literature | 2013 May
REPOSITORIES: biostudies-literature
Publications
Activation of transposable elements during aging and neuronal decline in Drosophila.
Li Wanhe W Prazak Lisa L Chatterjee Nabanita N Grüninger Servan S Krug Lisa L Theodorou Delphine D Dubnau Josh J
Nature neuroscience 20130407 5
We found that several transposable elements were highly active in Drosophila brain during normal aging. In addition, we found that mutations in Drosophila Argonaute 2 (Ago2) resulted in exacerbated transposon expression in the brain, progressive and age-dependent memory impairment, and shortened lifespan. These findings suggest that transposon activation may contribute to age-dependent loss of neuronal function. ...[more]
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