Ontology highlight
ABSTRACT:
SUBMITTER: Li H
PROVIDER: S-EPMC3823228 | biostudies-literature | 2012 Jul
REPOSITORIES: biostudies-literature
Li Hui H Gao Fei F Ma Lili L Jiang Junhong J Miao Jianing J Jiang Mingyu M Fan Yang Y Wang Lili L Wu Di D Liu Bo B Wang Weilin W Lui Vincent Chi Hang VC Yuan Zhengwei Z
Journal of cellular and molecular medicine 20120701 7
Neural tube defects (NTDs) are complex congenital malformations resulting from incomplete neurulation in embryo. Despite surgical repair of the defect, most of the patients who survive with NTDs have a multiple system handicap due to neuron deficiency of the defective spinal cord. In this study, we successfully devised a prenatal surgical approach and transplanted mesenchymal stem cells (MSCs) to foetal rat spinal column to treat retinoic acid induced NTDs in rat. Transplanted MSCs survived, gre ...[more]