Ontology highlight
ABSTRACT:
SUBMITTER: Wang H
PROVIDER: S-EPMC3823491 | biostudies-literature | 2008 Jan-Feb
REPOSITORIES: biostudies-literature
Wang Hu H Chen Chen C Song Xiaodong X Chen Jingzhou J Zhen Yisong Y Sun Kai K Hui Rutai R
Journal of cellular and molecular medicine 20071116 1
The cardiac ankyrin repeat kinase (CARK) gene, also named TNNI3K for its interaction with cardiac troponin I, is both a unique expression and heart-enriched gene. To understand the mechanisms of CARK gene expression and regulation, we first cloned the full-length mRNA sequence and mapped the transcription start site of the mouse CARK gene and characterized its promoter regions. Two transcriptional isoforms of the CARK gene were identified in mouse heart tissue. Truncation analysis of the CARK pr ...[more]