Ontology highlight
ABSTRACT:
SUBMITTER: Jilka RL
PROVIDER: S-EPMC3823639 | biostudies-literature | 2014 Jan
REPOSITORIES: biostudies-literature
Jilka Robert L RL O'Brien Charles A CA Roberson Paula K PK Bonewald Lynda F LF Weinstein Robert S RS Manolagas Stavros C SC
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 20140101 1
Skeletal aging is accompanied by decreased cancellous bone mass and increased formation of pores within cortical bone. The latter accounts for a large portion of the increase in nonvertebral fractures after age 65 years in humans. We selectively deleted Bak and Bax, two genes essential for apoptosis, in two types of terminally differentiated bone cells: the short-lived osteoblasts that elaborate the bone matrix, and the long-lived osteocytes that are immured within the mineralized matrix and cho ...[more]