Ontology highlight
ABSTRACT:
SUBMITTER: Uda Y
PROVIDER: S-EPMC8751595 | biostudies-literature | 2021 Dec
REPOSITORIES: biostudies-literature
Uda Yuhei Y Saini Vaibhav V Petty Christopher A CA Alshehri Majed M Shi Chao C Spatz Jordan M JM Santos Roberto R Newell Carly M CM Huang Tim Y TY Kochen Alejandro A Kim Ji W JW Constantinou Christodoulos K CK Saito Hiroaki H Held Kathryn D KD Hesse Eric E Pajevic Paola Divieti PD
Aging 20211230 24
Aging is accompanied by osteopenia, characterized by reduced bone formation and increased bone resorption. Osteocytes, the terminally differentiated osteoblasts, are regulators of bone homeostasis, and parathyroid hormone (PTH) receptor (PPR) signaling in mature osteoblasts/osteocytes is essential for PTH-driven anabolic and catabolic skeletal responses. However, the role of PPR signaling in those cells during aging has not been investigated. The aim of this study was to analyze the role of PTH ...[more]