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Cytoplasmic dynein heavy chain: the servant of many masters.

ABSTRACT: Cytoplasmic dynein is the main retrograde motor in all eukaryotic cells. This complex comprises different subunits assembled on a cytoplasmic dynein heavy chain 1 (DYNC1H1) dimer. Cytoplasmic dynein is particularly important for neurons because it carries essential signals and organelles from distal sites to the cell body. In the past decade, several mouse models have helped to dissect the numerous functions of DYNC1H1. Additionally, several DYNC1H1 mutations have recently been found in human patients that give rise to a broad spectrum of developmental and midlife-onset disorders. Here, we discuss the effects of mutations of mouse and human DYNC1H1 and how these studies are giving us new insight into the many critical roles DYNC1H1 plays in the nervous system.

SUBMITTER: Schiavo G

PROVIDER: S-EPMC3824068 | biostudies-literature | 2013 Nov

REPOSITORIES: biostudies-literature

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Cytoplasmic dynein heavy chain: the servant of many masters.

Schiavo Giampietro G Greensmith Linda L Hafezparast Majid M Fisher Elizabeth M C EM

Trends in neurosciences 20130910 11

Cytoplasmic dynein is the main retrograde motor in all eukaryotic cells. This complex comprises different subunits assembled on a cytoplasmic dynein heavy chain 1 (DYNC1H1) dimer. Cytoplasmic dynein is particularly important for neurons because it carries essential signals and organelles from distal sites to the cell body. In the past decade, several mouse models have helped to dissect the numerous functions of DYNC1H1. Additionally, several DYNC1H1 mutations have recently been found in human pa ...[more]

PMID: 24035135

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