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Degradable terpolymers with alkyl side chains demonstrate enhanced gene delivery potency and nanoparticle stability.

ABSTRACT: Degradable, cationic poly(?-amino ester)s (PBAEs) with alkyl side chains are developed for non-viral gene delivery. Nanoparticles formed from these PBAE terpolymers exhibit significantly enhanced DNA transfection potency and resistance to aggregation. These hydrophobic PBAE terpolymers, but not PBAEs lacking alkyl side chains, support interaction with PEG-lipid conjugates, facilitating their functionalization with shielding and targeting moieties and accelerating the in vivo translation of these materials.

SUBMITTER: Eltoukhy AA

PROVIDER: S-EPMC3824380 | biostudies-literature | 2013 Mar

REPOSITORIES: biostudies-literature

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Degradable terpolymers with alkyl side chains demonstrate enhanced gene delivery potency and nanoparticle stability.

Eltoukhy Ahmed A AA Chen Delai D Alabi Christopher A CA Langer Robert R Anderson Daniel G DG

Advanced materials (Deerfield Beach, Fla.) 20130104 10

Degradable, cationic poly(β-amino ester)s (PBAEs) with alkyl side chains are developed for non-viral gene delivery. Nanoparticles formed from these PBAE terpolymers exhibit significantly enhanced DNA transfection potency and resistance to aggregation. These hydrophobic PBAE terpolymers, but not PBAEs lacking alkyl side chains, support interaction with PEG-lipid conjugates, facilitating their functionalization with shielding and targeting moieties and accelerating the in vivo translation of these ...[more]

PMID: 23293063

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