Ontology highlight
ABSTRACT:
SUBMITTER: Eltoukhy AA
PROVIDER: S-EPMC3824380 | biostudies-literature | 2013 Mar
REPOSITORIES: biostudies-literature
Eltoukhy Ahmed A AA Chen Delai D Alabi Christopher A CA Langer Robert R Anderson Daniel G DG
Advanced materials (Deerfield Beach, Fla.) 20130104 10
Degradable, cationic poly(β-amino ester)s (PBAEs) with alkyl side chains are developed for non-viral gene delivery. Nanoparticles formed from these PBAE terpolymers exhibit significantly enhanced DNA transfection potency and resistance to aggregation. These hydrophobic PBAE terpolymers, but not PBAEs lacking alkyl side chains, support interaction with PEG-lipid conjugates, facilitating their functionalization with shielding and targeting moieties and accelerating the in vivo translation of these ...[more]