Ontology highlight
ABSTRACT:
SUBMITTER: Zhou W
PROVIDER: S-EPMC3824684 | biostudies-literature | 2013 Oct
REPOSITORIES: biostudies-literature
Zhou W W Fu X-Q XQ Zhang L-L LL Zhang J J Huang X X Lu X-H XH Shen L L Liu B-N BN Liu J J Luo H-S HS Yu J-P JP Yu H-G HG
Cell death & disease 20131010
The inherent resistance of tumors to DNA damage often limits the efficacy of chemotherapy. The aim of this work is to explore the potential mechanism for development of chemoresistance in gastric cancer. Our data revealed that AKT1 mRNA and protein expression were induced by doxorubicin (a chemotherapeutic agent); the doxorubicin-induced AKT1 expression and activation increased the binding of NF-kappaB on Notch1 DNA promoter and then promoted the Notch1 transcription and expression; enhanced exp ...[more]