Ontology highlight
ABSTRACT:
SUBMITTER: Shin HM
PROVIDER: S-EPMC1356346 | biostudies-literature | 2006 Jan
REPOSITORIES: biostudies-literature
Shin Hyun Mu HM Minter Lisa M LM Cho Ok Hyun OH Gottipati Sridevi S Fauq Abdul H AH Golde Todd E TE Sonenshein Gail E GE Osborne Barbara A BA
The EMBO journal 20051201 1
Notch1 specifically upregulates expression of the cytokine interferon-gamma in peripheral T cells through activation of NF-kappaB. However, how Notch mediates NF-kappaB activation remains unclear. Here, we examined the temporal relationship between Notch signaling and NF-kappaB induction during T-cell activation. NF-kappaB activation occurs within minutes of T-cell receptor (TCR) engagement and this activation is sustained for at least 48 h following TCR signaling. We used gamma-secretase inhibi ...[more]