Ontology highlight
ABSTRACT:
SUBMITTER: Bhusari S
PROVIDER: S-EPMC3825178 | biostudies-literature | 2011 Nov
REPOSITORIES: biostudies-literature
Bhusari Sachin S Yang Bing B Kueck Jessica J Huang Wei W Jarrard David F DF
The Prostate 20110322 15
<h4>Background</h4>Loss of imprinting (LOI) is an epigenetic alteration involving loss of parental origin-specific expression at normally imprinted genes. A LOI for IGF2, a paracrine growth factor, has been implicated in the development of prostate and other cancers. In the current study, we define IGF2 LOI in histologically normal prostate tissues in relationship to tumor foci and gene expression.<h4>Methods</h4>Microdissected tumor associated (TA) adjacent (2 mm) and distant (10 mm) tissues su ...[more]