Ontology highlight
ABSTRACT:
SUBMITTER: Hickey MJ
PROVIDER: S-EPMC3825732 | biostudies-literature | 2013 Oct
REPOSITORIES: biostudies-literature
Hickey Michelle J MJ Kasahara Noriyuki N Mueller Barbara M BM Kruse Carol A CA
Oncoimmunology 20130912 10
New treatments are needed for brain metastasis, which is associated with high morbidity and mortality. Two novel cellular and gene therapy modalities were evaluated in xenograft models for human breast cancer. The individual and especially the combined treatments with alloreactive cytotoxic T lymphocytes and replicating retroviral vectors coding for prodrug activating enzymes followed later with nontoxic prodrug demonstrated efficacy without off-target effects. ...[more]