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A novel method for the determination of isokinetic ratios and its application in the synthesis of two new positional scanning libraries.

ABSTRACT: A novel method for the direct evaluation of the equimolarity of the compounds contained in a mixture is presented. We applied the method toward calculating isokinetic ratios for the reaction between the amine termini of a resin bound peptide fragment and a sulfonyl chloride to produce equal molar mixtures of sulfonamides. The results of this study and the application of the method to the synthesis of two new positional scanning synthetic combinatorial libraries (PS-SCL) are discussed.

SUBMITTER: Giulianotti MA

PROVIDER: S-EPMC3825827 | biostudies-literature | 2012 Sep

REPOSITORIES: biostudies-literature

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A novel method for the determination of isokinetic ratios and its application in the synthesis of two new positional scanning libraries.

Giulianotti Marc A MA Debevec Ginamarie G Santos Radleigh G RG Maida Laura E LE Chen Wenteng W Ou Lili L Yu Yongping Y Dooley Colette T CT Houghten Richard A RA

ACS combinatorial science 20120828 9

A novel method for the direct evaluation of the equimolarity of the compounds contained in a mixture is presented. We applied the method toward calculating isokinetic ratios for the reaction between the amine termini of a resin bound peptide fragment and a sulfonyl chloride to produce equal molar mixtures of sulfonamides. The results of this study and the application of the method to the synthesis of two new positional scanning synthetic combinatorial libraries (PS-SCL) are discussed. ...[more]

PMID: 22913403

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