Ontology highlight
ABSTRACT:
SUBMITTER: Williams BD
PROVIDER: S-EPMC3826463 | biostudies-literature | 2013 Sep
REPOSITORIES: biostudies-literature
Williams Brett D BD Smith Amos B AB
Organic letters 20130823 17
An enantioselective total synthesis of the cytotoxic latrunculin congener (+)-18-epi-latrunculol A has been achieved. Key steps in the synthetic route include an acid-mediated enone cyclization/equilibration sequence, a Carreira alkynylation, and a late-stage Mitsunobu macrolactonization to construct the macrolide skeleton. ...[more]