Ontology highlight
ABSTRACT:
SUBMITTER: Thach DQ
PROVIDER: S-EPMC6980906 | biostudies-literature | 2020 Jan
REPOSITORIES: biostudies-literature
Angewandte Chemie (International ed. in English) 20191212 4
The ophiobolin sesterterpenes are notable plant pathogens which have recently elicited significant chemical and biological attention because of their intriguing carbogenic frameworks, reactive functionalities, and emerging anticancer profiles. Reported herein is a total synthesis of (+)-6-epi-ophiobolin A in 14 steps, a task which addresses construction of the synthetically challenging spirocyclic tetrahydrofuran motif as well as several other key stereochemical problems. This work demonstrates ...[more]