Ontology highlight
ABSTRACT:
SUBMITTER: Funamoto S
PROVIDER: S-EPMC3826621 | biostudies-literature | 2013
REPOSITORIES: biostudies-literature
Nature communications 20130101
Understanding the substrate recognition mechanism of γ-secretase is a key step for establishing substrate-specific inhibition of amyloid β-protein (Aβ) production. However, it is widely believed that γ-secretase is a promiscuous protease and that its substrate-specific inhibition is elusive. Here we show that γ-secretase distinguishes the ectodomain length of substrates and preferentially captures and cleaves substrates containing a short ectodomain. We also show that a subset of peptides contai ...[more]