Ontology highlight
ABSTRACT:
SUBMITTER: Bargieri DY
PROVIDER: S-EPMC3826631 | biostudies-literature | 2013
REPOSITORIES: biostudies-literature
Bargieri Daniel Y DY Andenmatten Nicole N Lagal Vanessa V Thiberge Sabine S Whitelaw Jamie A JA Tardieux Isabelle I Meissner Markus M Ménard Robert R
Nature communications 20130101
Apicomplexan parasites invade host cells by forming a ring-like junction with the cell surface and actively sliding through the junction inside an intracellular vacuole. Apical membrane antigen 1 is conserved in apicomplexans and a long-standing malaria vaccine candidate. It is considered to have multiple important roles during host cell penetration, primarily in structuring the junction by interacting with the rhoptry neck 2 protein and transducing the force generated by the parasite motor duri ...[more]