Ontology highlight
ABSTRACT:
SUBMITTER: Fang ZZ
PROVIDER: S-EPMC3826681 | biostudies-literature | 2013 Dec
REPOSITORIES: biostudies-literature
Fang Zhong-Ze ZZ He Rong-Rong RR Cao Yun-Feng YF Tanaka Naoki N Jiang Changtao C Krausz Kristopher W KW Qi Yunpeng Y Dong Pei-Pei PP Ai Chun-Zhi CZ Sun Xiao-Yu XY Hong Mo M Ge Guang-Bo GB Gonzalez Frank J FJ Ma Xiao-Chi XC Sun Hong-Zhi HZ
Journal of lipid research 20131010 12
Increased levels of bile acids (BAs) due to the various hepatic diseases could interfere with the metabolism of xenobiotics, such as drugs, and endobiotics including steroid hormones. UDP-glucuronosyltransferases (UGTs) are involved in the conjugation and elimination of many xenobiotics and endogenous compounds. The present study sought to investigate the potential for inhibition of UGT enzymes by BAs. The results showed that taurolithocholic acid (TLCA) exhibited the strongest inhibition toward ...[more]