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Bile Acids as Metabolic Regulators and Nutrient Sensors.

ABSTRACT: Bile acids facilitate nutrient absorption and are endogenous ligands for nuclear receptors that regulate lipid and energy metabolism. The brain-gut-liver axis plays an essential role in maintaining overall glucose, bile acid, and immune homeostasis. Fasting and feeding transitions alter nutrient content in the gut, which influences bile acid composition and pool size. In turn, bile acid signaling controls lipid and glucose use and protection against inflammation. Altered bile acid metabolism resulting from gene mutations, high-fat diets, alcohol, or circadian disruption can contribute to cholestatic and inflammatory diseases, diabetes, and obesity. Bile acids and their derivatives are valuable therapeutic agents for treating these inflammatory metabolic diseases.

SUBMITTER: Chiang JYL

PROVIDER: S-EPMC6996089 | biostudies-literature | 2019 Aug

REPOSITORIES: biostudies-literature

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Bile Acids as Metabolic Regulators and Nutrient Sensors.

Chiang John Y L JYL Ferrell Jessica M JM

Annual review of nutrition 20190424

Bile acids facilitate nutrient absorption and are endogenous ligands for nuclear receptors that regulate lipid and energy metabolism. The brain-gut-liver axis plays an essential role in maintaining overall glucose, bile acid, and immune homeostasis. Fasting and feeding transitions alter nutrient content in the gut, which influences bile acid composition and pool size. In turn, bile acid signaling controls lipid and glucose use and protection against inflammation. Altered bile acid metabolism res ...[more]

PMID: 31018107

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Metabolic Profiling of Bile Acids in the Urine of Patients with Alcohol-Associated Liver Disease.

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| S-EPMC5218478 | biostudies-literature

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