Ontology highlight
ABSTRACT:
SUBMITTER: Tan SJ
PROVIDER: S-EPMC3826715 | biostudies-literature | 2013
REPOSITORIES: biostudies-literature
Tan Swee Jin SJ Kee Michelle Z L MZ Mathuru Ajay Sriram AS Burkholder William F WF Jesuthasan Suresh J SJ
PloS one 20131108 11
Single cell techniques permit the analysis of cellular properties that are obscured by studying the average behavior of cell populations. One way to determine how gene expression contributes to phenotypic differences among cells is to combine functional analysis with transcriptional profiling of single cells. Here we describe a microfluidic device for monitoring the responses of single cells to a ligand and then collecting cells of interest for transcriptional profiling or other assays. As a tes ...[more]