Ontology highlight
ABSTRACT:
SUBMITTER: Crispo M
PROVIDER: S-EPMC3827052 | biostudies-literature | 2013
REPOSITORIES: biostudies-literature
Crispo Martina M Van Maele Laurye L Tabareau Julien J Cayet Delphine D Errea Agustina A Ferreira Ana María AM Rumbo Martin M Sirard Jean Claude JC
PloS one 20131112 11
The chemokine CCL20, the unique ligand of CCR6 functions as an attractant of immune cells. Expression of CCL20 is induced by Toll-like Receptor (TLR) signaling or proinflammatory cytokine stimulation. However CCL20 is also constitutively produced at specific epithelial sites of mucosa. This expression profile is achieved by transcriptional regulation. In the present work we characterized regulatory features of mouse Ccl20 gene. Transcriptional fusions between the mouse Ccl20 promoter and the fir ...[more]