Ontology highlight
ABSTRACT:
SUBMITTER: Chen M
PROVIDER: S-EPMC3827077 | biostudies-literature | 2013
REPOSITORIES: biostudies-literature
Chen Mengjie M Gunel Murat M Zhao Hongyu H
PloS one 20131112 11
Whole genome sequencing of matched tumor-normal sample pairs is becoming routine in cancer research. However, analysis of somatic copy-number changes from sequencing data is still challenging because of insufficient sequencing coverage, unknown tumor sample purity and subclonal heterogeneity. Here we describe a computational framework, named SomatiCA, which explicitly accounts for tumor purity and subclonality in the analysis of somatic copy-number profiles. Taking read depths (RD) and lesser al ...[more]