Ontology highlight
ABSTRACT:
SUBMITTER: Grenning AJ
PROVIDER: S-EPMC3827786 | biostudies-literature | 2013 Jul
REPOSITORIES: biostudies-literature
The Journal of organic chemistry 20130701 14
Herein we present the development of asymmetric deacylative allylation of ketone enolates. The reaction directly couples readily available ketone pronucleophiles with allylic alcohols using facile retro-Claisen cleavage to form reactive intermediates in situ. The simplicity and robustness of the reaction conditions is demonstrated by the preparation of >6 g of an allylated tetralone from commercially available materials. Furthermore, use of nonracemic PHOX ligands allows intermolecular formation ...[more]